- Preparation of Silver-doped Hydroxyapatite Using Sol-gel Method
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Byung-Bae Mun, Ho-Kun Kim
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J Korean Powder Metall Inst. 2005;12(6):428-432.
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DOI: https://doi.org/10.4150/KPMI.2005.12.6.428
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 Abstract
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- In the present study, silver-doped antibacterial hydroxyapatites were successfully prepared by the sol-gel method. For the starting solution, the molar ratio of Ca(NO_3)_2cdot4H_2O, P(OC_2H_5)_3,;C_2H_5OH,;and;H_O was set to 0.075:0.045:20:0.135; AgNO_3 was added to a ratio of Ag to total cation concentration of 0.5-12 mol%. The prepared sol was dried at 100°C for 48h and heat-treated at 1000°C for 2h to obtain particles in the 200-500nm size range. The product from the synthesis of silver-doped hydroxyapatite was investigated through X-ray diffraction experiments and scanning electron microscopy. The product showed high antibacterial properties, with a disinfection ratio of Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 25922) over 99.9°C as calculated from an antimicrobial effects evaluation by the shake flask method.
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